Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | TMPRSS11D | O60235 | 11/20 | 0.41 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | PLG | P00747 | 5/20 | 0.41 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sarcosine SCHEMBL8800822 | 0.95 | TMPRSS11D (0.43) | SLC1A3SLC1A2SLC1A1TMPRSS11DF2 | |
| Arginine SCHEMBL7364644 | 0.89 | ITGB3 (0.40) | SLC1A3SLC1A2SLC1A1TMPRSS11DF2 | |
| SCHEMBL8799340 | 0.87 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1TMPRSS11DF2 | |
| SCHEMBL8597124 | 0.87 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1TMPRSS11DF2 | |
| Arginine SCHEMBL7359770 | 0.83 | ITGB3 (0.40) | F2ITGB3ITGA2BITGAVMMP1 | |
| Arginine SCHEMBL5598764 | 0.79 | OTC (0.46) | — | |
| SCHEMBL18419482 | 0.78 | F10 (0.47) | TMPRSS11DF2F10PLGITGB3 | |
| Arginine SCHEMBL17164594 | 0.75 | AKR1B1 (0.45) | SLC1A3SLC1A1 | |
| Arginine SCHEMBL17164595 | 0.75 | AKR1B1 (0.45) | SLC1A3SLC1A1 | |
| Arginine SCHEMBL7428963 | 0.75 | GRIK1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |