Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | TMPRSS11D | O60235 | 5/20 | 0.36 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 5/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7359381 | 0.89 | SLC1A3 (0.41) | ITGB3ITGA2BITGAVTMPRSS11DF10 | |
| Arginine SCHEMBL7364647 | 0.85 | TBXAS1 (0.34) | FOLH1KISS1RTBXAS1NPY4R | |
| Sarcosine SCHEMBL7358185 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| Sarcosine SCHEMBL7358194 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| Sarcosine SCHEMBL8800822 | 0.84 | TMPRSS11D (0.43) | ITGB3ITGA2BITGAVTMPRSS11DF10 | |
| Arginine SCHEMBL7359463 | 0.81 | CPB2 (0.36) | FOLH1KISS1RTBXAS1 | |
| SCHEMBL8799340 | 0.76 | SLC1A3 (0.49) | ITGB3ITGA2BITGAVTMPRSS11DF10 | |
| SCHEMBL8597124 | 0.76 | SLC1A3 (0.49) | ITGB3ITGA2BITGAVTMPRSS11DF10 | |
| SCHEMBL7360215 | 0.74 | GPR132 (0.45) | ITGB3ITGA2BITGAVGPR132TBXAS1 | |
| SCHEMBL7360209 | 0.74 | GPR132 (0.45) | ITGB3ITGA2BITGAVGPR132TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0801654-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |