Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 8/20 | 0.37 |
| ▸ | MMP9 | P14780 | 8/20 | 0.37 |
| ▸ | MMP8 | P22894 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 3/20 | 0.36 |
| ▸ | MMP14 | P50281 | 3/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7359381 | 0.83 | SLC1A3 (0.41) | ITGB3ITGA2BMMP2MMP9MMP1 | |
| SCHEMBL6877985 | 0.78 | ITGAV (0.57) | ITGB3ITGA2BMMP2MMP9MMP8 | |
| SCHEMBL8492995 | 0.78 | ITGAV (0.57) | ITGB3ITGA2BMMP2MMP9MMP8 | |
| Sarcosine SCHEMBL8800822 | 0.78 | TMPRSS11D (0.43) | ITGB3ITGA2BMMP2MMP9MMP1 | |
| Arginine SCHEMBL5598764 | 0.77 | OTC (0.46) | — | |
| SCHEMBL7420373 | 0.75 | SLC1A3 (0.53) | ITGB3ITGA2BF2ITGAV | |
| SCHEMBL7420368 | 0.75 | SLC1A3 (0.53) | ITGB3ITGA2BF2ITGAV | |
| SCHEMBL3448325 | 0.74 | MMP9 (0.58) | ITGB3ITGA2BMMP2MMP9MMP8 | |
| SCHEMBL3448321 | 0.74 | MMP9 (0.58) | ITGB3ITGA2BMMP2MMP9MMP8 | |
| Arginine SCHEMBL28410966 | 0.74 | LARS1 (0.41) | ITGB3ITGA2BMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |