Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18760165 | 0.81 | NPC1 (0.67) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL9775789 | 0.76 | ALDH1A1 (0.58) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL23121264 | 0.72 | NPC1 (0.62) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL7359470 | 0.72 | NPSR1 (0.56) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL7335367 | 0.72 | NPC1 (0.55) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL21852785 | 0.71 | NPC1 (0.64) | NPC1RAB9ANPSR1SMN1; SMN2HTT | |
| SCHEMBL7355352 | 0.71 | LMNA (0.56) | NPC1RAB9ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL7359187 | 0.71 | KMT2A (0.58) | NPC1RAB9ALMNASMN1; SMN2HDAC1 | |
| SCHEMBL7360125 | 0.71 | NPC1 (0.55) | NPC1RAB9ALMNASMN1; SMN2HDAC1 | |
| SCHEMBL7959722 | 0.70 | NPC1 (0.63) | NPC1RAB9ANPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |