Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.54 |
| ▸ | MMP2 | P08253 | 16/20 | 0.54 |
| ▸ | MMP13 | P45452 | 16/20 | 0.54 |
| ▸ | MMP14 | P50281 | 8/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP9 | P14780 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359821 | 0.87 | ADAM17 (0.65) | ADAM17MMP2MMP13MMP14MMP1 | |
| Trifluoroacetic Acid SCHEMBL7364489 | 0.83 | ADAM17 (0.58) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7363306 | 0.82 | ADAM17 (0.58) | ADAM17MMP2MMP13MMP14MMP1 | |
| Trifluoroacetic Acid SCHEMBL7360301 | 0.82 | ADAM17 (0.63) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7366227 | 0.79 | ADAM17 (0.71) | ADAM17MMP2MMP13MMP14MMP1 | |
| Trifluoroacetic Acid SCHEMBL7357783 | 0.79 | MMP2 (0.53) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7364287 | 0.78 | ADAM17 (0.61) | ADAM17MMP2MMP13MMP14MMP1 | |
| Trifluoroacetic Acid SCHEMBL3948358 | 0.77 | ADAM17 (0.76) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7362009 | 0.77 | ADAM17 (0.64) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7357854 | 0.76 | ADAM17 (0.71) | ADAM17MMP2MMP13MMP14MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020086890-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors | AMERICAN CYANAMID COMPANY | 2002-07-04 | — | — | US | claimed |
| EP-1147085-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044723-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086890-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors | MMP17, MMP1, MMP9 | ADAM17 12/4885MMP2 11/4885MMP13 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.