Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504971 | 0.83 | LMNA (0.44) | MAPTHTTNPSR1LMNACA12 | |
| SCHEMBL7360175 | 0.80 | TSHR (0.46) | TSHRSMN1; SMN2SNCAALDH1A1HSD17B10 | |
| SCHEMBL9508137 | 0.74 | ALDH1A1 (0.45) | TSHRSMN1; SMN2SNCAALDH1A1HSD17B10 | |
| SCHEMBL4742301 | 0.73 | TRPA1 (0.50) | SNCAALDH1A1HSD17B10TDP1POLB | |
| SCHEMBL5191452 | 0.72 | CA2 (0.41) | SNCATDP1MEN1MAPTMAPK1 | |
| SCHEMBL9186453 | 0.72 | NOX1 (0.55) | TSHRSMN1; SMN2SNCAALDH1A1HSD17B10 | |
| SCHEMBL5191816 | 0.71 | PLEC (0.46) | TSHRSNCAALDH1A1TDP1POLB | |
| SCHEMBL9185974 | 0.71 | NOX1 (0.54) | TSHRSMN1; SMN2SNCAALDH1A1HSD17B10 | |
| SCHEMBL8131523 | 0.70 | SNCA (0.53) | TSHRSMN1; SMN2SNCAALDH1A1HSD17B10 | |
| SCHEMBL11661952 | 0.70 | BCHE (0.39) | POLBTP53LMNAHDAC6GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812420-A1 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS | Nicholas Piramal India Limited (IN) | 2007-08-01 | — | — | EP | claimed |
| WO-2006051476-A1 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2006-05-18 | — | — | WO | claimed |