Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.53 |
| ▸ | MMP3 | P08254 | 7/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 10/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.48 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360065 | 0.87 | MMP1 (0.51) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7363512 | 0.79 | MMP3 (0.45) | MMP1MMP3MMP2MMP8 | |
| SCHEMBL7357715 | 0.77 | NPC1 (0.49) | MMP1MMP9MMP8 | |
| SCHEMBL7363203 | 0.76 | MMP1 (0.40) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL27538399 | 0.76 | MMP1 (0.52) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL6898025 | 0.76 | MMP1 (0.52) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL8749847 | 0.76 | NAALAD2 (0.52) | MMP9MMP2MMP7 | |
| SCHEMBL7354243 | 0.76 | NAALAD2 (0.52) | MMP9MMP2MMP7 | |
| SCHEMBL7357691 | 0.76 | CTSL (0.45) | MMP1MMP3MMP2MMP8 | |
| SCHEMBL7357664 | 0.75 | ALDH1A1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691382-A | ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |