SCHEMBL7360469

SCHEMBL7360469

CCOC(=O)[C@H]1N[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nn1cccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.44
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
FPR2 P25090 1/20 0.41
MMP8 P22894 1/20 0.40
TACR1 P25103 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 1/20 0.38
THRB P10828 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
TP53 P04637 1/20 0.38
CAPN1 P07384 1/20 0.38
CTSL P07711 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7361795 0.85 L3MBTL1 (0.51) L3MBTL1GAAFPR2ALDH1A1HSD17B10
SCHEMBL7354780 0.85 LMNA (0.49) L3MBTL1GAARAB9AFPR2MMP8
SCHEMBL7356396 0.84 CAPN1 (0.53) FPR2ALDH1A1CYP2C9CYP2C19TP53
SCHEMBL7359406 0.84 MMP1 (0.49) L3MBTL1MMP8
SCHEMBL8308171 0.83 USP30 (0.38) SMN1; SMN2ALDH1A1CTSLCTSSCTSK
SCHEMBL7361887 0.82 MMP9 (0.55) L3MBTL1MMP8ALDH1A1CTSL
SCHEMBL7360491 0.82 TACR1 (0.48) L3MBTL1TACR1CTSLCTSBCTSS
SCHEMBL7353746 0.82 MMP9 (0.55) L3MBTL1MMP8ALDH1A1CTSL
SCHEMBL7361188 0.82 BACE1 (0.45) L3MBTL1MMP8SMN1; SMN2CAPN1CTSL
SCHEMBL7363926 0.82 L3MBTL1 (0.47) L3MBTL1MMP8SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0753003-B1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-06-16 EP disclosed
US-5668128-A INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-16 US disclosed
EP-0753003-A1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-01-15 EP disclosed
WO-1995028416-A1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-26 WO disclosed