Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 8/20 | 0.43 |
| ▸ | CA2 | P00918 | 8/20 | 0.43 |
| ▸ | CA5A | P35218 | 8/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7359600 | 0.92 | ITGB3 (0.47) | CYP1A2CYP2C19CA1CA2CA5A | |
| Arginine SCHEMBL7363181 | 0.90 | ITGB3 (0.43) | CYP1A2CYP2C19CA1CA2CA5A | |
| Sarcosine SCHEMBL8800845 | 0.87 | ITGB3 (0.49) | CYP1A2CYP2C19CA1CA2CA5A | |
| Arginine SCHEMBL28791955 | 0.86 | F2 (0.47) | CYP1A2CYP2C19CA1CA2CA5A | |
| Sarcosine SCHEMBL7363936 | 0.83 | ALDH1A1 (0.58) | CYP1A2CYP2C19CA1CA2CA5A | |
| Arginine SCHEMBL7363826 | 0.82 | F2 (0.39) | CYP1A2CYP2C19CA1CA2CA5A | |
| Arginine SCHEMBL7359466 | 0.79 | F10 (0.36) | CYP1A2CYP2C19CA1CA2CA5A | |
| SCHEMBL7362007 | 0.79 | ALDH1A1 (0.63) | CYP1A2CYP2C19CA1CA2CA5A | |
| SCHEMBL28791954 | 0.78 | F2 (0.48) | CYP1A2CYP2C19CA1CA2CA5A | |
| Arginine SCHEMBL5598764 | 0.73 | OTC (0.46) | CYP1A2CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |