Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349704 | 0.78 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7358332 | 0.74 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7354097 | 0.74 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL15093571 | 0.57 | PNMT (0.40) | BRD4STAT3 | |
| SCHEMBL16632833 | 0.57 | PKM (0.42) | — | |
| SCHEMBL29727517 | 0.56 | LMNA (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL871319 | 0.56 | LMNA (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL19865239 | 0.56 | ACHE (0.41) | — | |
| SCHEMBL4906168 | 0.55 | IDO1 (0.41) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7360811 | 0.55 | GABRG2 (0.71) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |