Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578350 | 0.84 | MAPT (0.50) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL514483 | 0.77 | HSD17B10 (0.56) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL7916733 | 0.77 | TSHR (0.44) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL7365151 | 0.77 | TSHR (0.44) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL30208519 | 0.76 | ACHE (0.56) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL11223878 | 0.76 | MAPT (0.40) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL11223881 | 0.76 | MAPT (0.40) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL17629196 | 0.76 | MAPT (0.50) | MAPTMEN1KMT2AHSD17B10ACHE | |
| SCHEMBL27830410 | 0.73 | ALDH1A1 (0.68) | MEN1KMT2AHSD17B10ACHEALDH1A1 | |
| SCHEMBL11225755 | 0.73 | ACHE (0.51) | MAPTMEN1KMT2AHSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |