Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101389 | 0.87 | MAPT (0.55) | MAPTPOLB | |
| SCHEMBL450333 | 0.75 | — | — | |
| SCHEMBL3643718 | 0.72 | PLA2G7 (0.36) | MAPTTLR4POLB | |
| SCHEMBL11062359 | 0.71 | ACHE (0.33) | ACHE | |
| SCHEMBL15395767 | 0.70 | — | — | |
| SCHEMBL1021859 | 0.68 | — | — | |
| SCHEMBL2736475 | 0.67 | USP2 (0.33) | MAPT | |
| SCHEMBL6639439 | 0.67 | GLA (0.38) | MAPT | |
| SCHEMBL10248293 | 0.64 | LMNA (0.36) | CA1CA9POLB | |
| SCHEMBL6901038 | 0.64 | PTPN1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642489-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5362915-A | Inhibitors of enzymes/hydrolases; antiallergens, antiinflammatory agents | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-11-08 | — | — | US | disclosed |
| WO-1993007111-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |
| EP-0523138-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015451-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1991-10-17 | — | — | WO | disclosed |