Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | YAP1 | P46937 | 9/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCL5 | P13501 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836339 | 0.88 | YAP1 (0.44) | ITGB3ITGA2BYAP1CHRM4P2RX7 | |
| SCHEMBL7835873 | 0.83 | YAP1 (0.41) | YAP1CHRM4P2RX7CCKBR | |
| SCHEMBL7833217 | 0.83 | GRIN2B (0.42) | YAP1CHRM4P2RX7 | |
| SCHEMBL7357897 | 0.83 | YAP1 (0.46) | YAP1CHRM4P2RX7 | |
| SCHEMBL7839324 | 0.82 | ITGB3 (0.44) | ITGB3ITGA2BYAP1MGLLCHRM4 | |
| SCHEMBL7836103 | 0.80 | CTSG (0.43) | ITGB3ITGA2BYAP1CHRM4 | |
| SCHEMBL7833800 | 0.79 | YAP1 (0.44) | ITGB3ITGA2BYAP1CHRM4P2RX7 | |
| SCHEMBL7833534 | 0.78 | YAP1 (0.43) | ITGB3ITGA2BYAP1CHRM4CCR1 | |
| SCHEMBL7837038 | 0.78 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL7835452 | 0.78 | PRSS1 (0.44) | ITGB3ITGA2BYAP1CHRM4CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800516-B1 | FIBRINOGEN RECEPTOR ANTAGONISTS HAVING SUBSTITUTED (b)-AMINO ACID RESIDUES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | NIPPON STEEL CORP (JP) | 2001-09-19 | — | — | EP | disclosed |
| US-5866592-A | Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same | NIPPON STEEL CORPORATION (JP) | 1999-02-02 | — | — | US | disclosed |
| WO-1996020172-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS HAVING SUBSTITUTED β-AMINO ACID RESIDUES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | NIPPON STEEL CORPORATION (JP) | 1996-07-04 | — | — | WO | disclosed |