Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 2/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431867 | 0.90 | BMP1 (0.41) | NMT2NMT1KDM4CFOLH1KDM4A | |
| SCHEMBL7354898 | 0.89 | KDM4C (0.43) | NMT2NMT1KDM4CFOLH1KDM4A | |
| SCHEMBL7358045 | 0.78 | KDM4C (0.39) | KDM4CKDM4APHF8KDM2AMMP1 | |
| SCHEMBL7363203 | 0.77 | MMP1 (0.40) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL7360065 | 0.76 | MMP1 (0.51) | MMP1MMP3MMP9 | |
| SCHEMBL6411900 | 0.75 | MMP3 (0.42) | MMP1MMP3MMP9ADAM17 | |
| Hydrochloric Acid SCHEMBL6897077 | 0.73 | NMT2 (0.38) | NMT2NMT1FOLH1SIRT6SIRT1 | |
| SCHEMBL6416552 | 0.73 | MMP1 (0.54) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL6416222 | 0.73 | MMP1 (0.39) | FOLH1MMP1MMP3MMP9ADAM17 | |
| SCHEMBL7536562 | 0.73 | FDPS (0.32) | KDM4CKDM4APHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691382-A | ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |