Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661515 | 0.90 | CCNE1 (0.54) | TK1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7672863 | 0.88 | PDGFRA (0.52) | TK1PDGFRACCNE1CDK2TAAR1 | |
| SCHEMBL7201278 | 0.86 | CDK2 (0.44) | TK1PDGFRACCNE1CDK2TAAR1 | |
| SCHEMBL7358070 | 0.84 | PDGFRA (0.55) | PDGFRACCNE1CDK2TAAR1 | |
| SCHEMBL7358271 | 0.84 | CCNE1 (0.51) | TK1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7674156 | 0.83 | HPGD (0.51) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7668634 | 0.81 | CCNE1 (0.54) | TK1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL24450806 | 0.81 | ADORA3 (0.56) | CCNE1CDK2CDK1 | |
| SCHEMBL7667654 | 0.80 | CCNE1 (0.53) | TK1PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7674300 | 0.80 | CTSL (0.50) | PDGFRACCNE1CDK2CTSLCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |
| WO-2000037471-A1 | 2-AMINO-9-ALKYLPURINES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |