Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 8/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673595 | 0.94 | KDM4E (0.45) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7358873 | 0.90 | CTSL (0.46) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7661515 | 0.90 | CCNE1 (0.54) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7674302 | 0.86 | PDGFRA (0.44) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7666144 | 0.86 | CDK4 (0.45) | CTSLCDK2CCNE1PDGFRACDK4 | |
| SCHEMBL7672863 | 0.86 | PDGFRA (0.52) | CDK2CCNE1PDGFRA | |
| SCHEMBL7666120 | 0.84 | PDGFRA (0.49) | CTSLCDK2CCNE1PDGFRANPC1 | |
| SCHEMBL7674135 | 0.84 | PDGFRA (0.43) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7672132 | 0.83 | GALR2 (0.44) | CTSLCDK1CDK2CCNE1PDGFRA | |
| SCHEMBL7672897 | 0.82 | LMNA (0.50) | CDK2CCNE1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |