Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.59 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 4/20 | 0.56 |
| ▸ | CTSS | P25774 | 4/20 | 0.56 |
| ▸ | KYNU | Q16719 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386880 | 0.91 | SIRT2 (0.67) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1111001 | 0.87 | SIRT2 (0.60) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1111018 | 0.87 | SIRT2 (0.60) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1111004 | 0.87 | SIRT2 (0.60) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL11685409 | 0.86 | CTSL (0.56) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL26222759 | 0.86 | SIRT2 (0.74) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1199556 | 0.86 | SIRT2 (0.74) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1840309 | 0.85 | SIRT2 (0.61) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL1840311 | 0.85 | SIRT2 (0.61) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL7362144 | 0.85 | SIRT2 (0.67) | SIRT2SIRT1SIRT3CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |