Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398689 | 0.92 | ALOX12 (0.46) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| SCHEMBL7366117 | 0.84 | P4HTM (0.53) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| SCHEMBL7396948 | 0.79 | ABL1 (0.47) | RAB9AMAPTLMNAALDH1A1POLB | |
| SCHEMBL30461131 | 0.79 | RAB9A (0.64) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| SCHEMBL13575692 | 0.76 | NPC1 (0.45) | NPC1MAPTPOLBNOTUM | |
| SCHEMBL695196 | 0.75 | CYP1A2 (0.46) | ALDH1A1L3MBTL1KDM4ENOTUMDYRK1A | |
| SCHEMBL27617094 | 0.75 | RAB9A (0.56) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| SCHEMBL5070333 | 0.75 | MAPT (0.56) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| SCHEMBL7396951 | 0.75 | KMT2A (0.62) | RAB9ANPC1MAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7349133 | 0.75 | METAP2 (0.42) | RAB9ANPC1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| US-4514568-A | 5-(4-Nitrophenyl)-2(1H)-pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-30 | — | — | US | disclosed |
| US-4514568-A | 5-(4-Nitrophenyl)-2(1H)-pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-30 | — | — | US | disclosed |
| US-4514568-A | 5-(4-Nitrophenyl)-2(1H)-pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-30 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |