Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MITF | O75030 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396951 | 0.87 | KMT2A (0.62) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL7398689 | 0.84 | ALOX12 (0.46) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7364055 | 0.84 | RAB9A (0.48) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL7398136 | 0.83 | POLB (0.55) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL7391714 | 0.83 | PTPN1 (0.67) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| Bromide SCHEMBL10730898 | 0.82 | PTPN1 (0.65) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7396608 | 0.82 | GAA (0.56) | KMT2APOLBRAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL16367722 | 0.78 | KMT2A (0.76) | P4HTMMEN1KMT2APOLBMITF | |
| SCHEMBL23898948 | 0.77 | KMT2A (0.83) | P4HTMMEN1KMT2APOLBMITF | |
| SCHEMBL8572381 | 0.77 | KMT2A (0.83) | P4HTMMEN1KMT2APOLBMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |