Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363475 | 0.87 | CTSS (0.30) | CTSS | |
| SCHEMBL7364034 | 0.87 | CTSS (0.30) | CTSS | |
| SCHEMBL7360069 | 0.86 | ATM (0.39) | CTSKATMCTSLCTSBCTSS | |
| SCHEMBL7360310 | 0.79 | CTSK (0.35) | CTSKATMCTSLCTSBCTSH | |
| SCHEMBL969953 | 0.78 | CTSK (0.36) | CTSKATMCTSLCTSBCTSH | |
| SCHEMBL970772 | 0.78 | CTSK (0.36) | CTSKATMCTSLCTSBCTSH | |
| Hydrochloric Acid SCHEMBL7364666 | 0.72 | HDAC3 (0.31) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL10425979 | 0.72 | HDAC3 (0.31) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL9534696 | 0.72 | HDAC3 (0.31) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10669320 | 0.72 | CTSK (0.44) | CTSKHDAC4HDAC1HDAC6CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270234-A2 | Renin inhibitors | PFIZER INC. (US) | 1988-06-08 | — | — | EP | disclosed |
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |