Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | USP19 | O94966 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364108 | 0.86 | CTSK (0.33) | ATMCTSLCTSBCTSSCTSK | |
| SCHEMBL7364034 | 0.82 | CTSS (0.30) | CTSS | |
| SCHEMBL7363475 | 0.82 | CTSS (0.30) | CTSS | |
| SCHEMBL2436515 | 0.80 | MEN1 (0.39) | MMP1ALDH1A1MMP13 | |
| SCHEMBL9817901 | 0.76 | CACNA1G (0.39) | ATMHSD11B1CTSLCTSBCTSS | |
| SCHEMBL9876609 | 0.76 | REN (0.44) | CTSSCTSK | |
| SCHEMBL2436776 | 0.75 | UGT1A1 (0.39) | — | |
| SCHEMBL2438073 | 0.75 | UGT1A1 (0.39) | — | |
| SCHEMBL7360310 | 0.74 | CTSK (0.35) | ATMCTSLCTSBCTSSCTSK | |
| SCHEMBL969953 | 0.73 | CTSK (0.36) | ATMCTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270234-A2 | Renin inhibitors | PFIZER INC. (US) | 1988-06-08 | — | — | EP | disclosed |
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |