Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361913 | 0.95 | ALOX15 (0.40) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7479315 | 0.95 | ALOX15 (0.41) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7469657 | 0.94 | MAPT (0.44) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7169944 | 0.92 | IDO1 (0.48) | IDO1TDO2CTSLCTSSCTSK | |
| SCHEMBL7478564 | 0.90 | ALOX15 (0.44) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7364535 | 0.90 | ALOX15 (0.41) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7374585 | 0.90 | MMP2 (0.44) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7164999 | 0.89 | IDO1 (0.44) | IDO1TDO2CTSLCTSKITGB3 | |
| SCHEMBL7479990 | 0.88 | HSD17B10 (0.40) | ALOX15HSD17B10MAPK1HTTL3MBTL1 | |
| SCHEMBL7169155 | 0.88 | ITGB3 (0.46) | IDO1TDO2CTSLCTSKITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964856-B1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 2002-10-09 | — | — | EP | disclosed |
| EP-0964856-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998035949-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 1998-08-20 | — | — | WO | disclosed |