Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365662 | 0.91 | HPGD (0.55) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B | |
| SCHEMBL7364396 | 0.89 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B | |
| SCHEMBL7360999 | 0.88 | HPGD (0.53) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B | |
| SCHEMBL7370206 | 0.87 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL7367645 | 0.85 | F2RL3 (0.55) | ALDH1A1SMN1; SMN2HPGDTSHRMEN1 | |
| SCHEMBL7369736 | 0.85 | TSHR (0.45) | ALDH1A1SMN1; SMN2HPGDTSHRMEN1 | |
| SCHEMBL7369005 | 0.85 | PDE4A (0.51) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B | |
| SCHEMBL7370605 | 0.84 | KDM4E (0.48) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B | |
| SCHEMBL7370600 | 0.83 | MEN1 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL7364707 | 0.83 | HPGD (0.52) | ALDH1A1SMN1; SMN2HPGDTSHRKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |