Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 3/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY4R | P50391 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sarcosine SCHEMBL7358190 | 0.87 | SMN1; SMN2 (0.39) | TBXAS1ANPEPALDH1A1ERAP2ERAP1 | |
| Arginine SCHEMBL7364644 | 0.85 | ITGB3 (0.40) | TBXAS1KISS1RFOLH1NPY4R | |
| Arginine SCHEMBL7359466 | 0.82 | F10 (0.36) | — | |
| Arginine SCHEMBL7359381 | 0.76 | SLC1A3 (0.41) | — | |
| Arginine SCHEMBL5598764 | 0.72 | OTC (0.46) | KMT2A | |
| Arginine SCHEMBL14861498 | 0.71 | SLC7A5 (0.59) | ANPEPRNPEPDNPEPNPY1RNPY4R | |
| Arginine SCHEMBL385198 | 0.71 | SLC7A5 (0.59) | ANPEPRNPEPDNPEPNPY1RNPY4R | |
| Arginine SCHEMBL1537371 | 0.71 | SLC7A5 (0.59) | ANPEPRNPEPDNPEPNPY1RNPY4R | |
| Arginine SCHEMBL4795238 | 0.71 | SLC7A5 (0.59) | ANPEPRNPEPDNPEPNPY1RNPY4R | |
| Arginine SCHEMBL9482082 | 0.71 | SLC7A5 (0.59) | ANPEPRNPEPDNPEPNPY1RNPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0801654-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |