SCHEMBL7365793

SCHEMBL7365793

CC1OC(=O)C(Cc2ccccc2)=C1O

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
MAPK1 P28482 1/20 0.44
HIF1A Q16665 1/20 0.44
APP P05067 1/20 0.40
SHBG P04278 1/20 0.38
IDH1 O75874 1/20 0.38
LMNA P02545 1/20 0.37
CALM1 P0DP23 1/20 0.37
ALDH1A1 P00352 3/20 0.36
NQO1 P15559 1/20 0.36
KDM4E B2RXH2 1/20 0.36
BCL2 P10415 1/20 0.36
BCL2L1 Q07817 1/20 0.36
DAO P14920 1/20 0.36
CNR2 P34972 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9423154 0.73 LMNA (0.43) CYP1A2HIF1ALMNAALDH1A1
SCHEMBL17480820 0.69 CYP1A2 (0.44) CYP1A2CYP2C9MAPK1HIF1ASHBG
SCHEMBL305339 0.66 CALM1 (0.52) CYP1A2CYP2C9MAPK1HIF1AIDH1
SCHEMBL382020 0.66 PTPN1 (0.36) ALDH1A1
Phenylacetic Acid SCHEMBL8860243 0.66 AKR1B1 (0.65) LMNAALDH1A1
SCHEMBL16149017 0.66 CYP1A2 (0.47) CYP1A2CYP2C9MAPK1HIF1AIDH1
SCHEMBL8530970 0.66 PTGS2 (0.52) CYP1A2CYP2C9MAPK1HIF1ASHBG
SCHEMBL16432883 0.66 CTRB1 (0.39) CYP1A2CYP2C9MAPK1HIF1ACALM1
SCHEMBL3895689 0.64 TSHR (0.47) CYP1A2CYP2C9MAPK1HIF1AIDH1
SCHEMBL257301 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6060600-A TREATMENT OF AIDS AND OTHER DISEASES CAUSED BY RETROVIRUSES PHARMACIA & UPJOHN COMPANY (US) 2000-05-09 US disclosed
US-5977169-A FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES PHARMACIA & UPJOHN COMPANY 1999-11-02 US disclosed
EP-0817786-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES PHARMACIA & UPJOHN COMPANY (US) 1998-01-14 EP disclosed
WO-1996029333-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES PHARMACIA & UPJOHN COMPANY (US) 1996-09-26 WO disclosed
EP-0720607-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES PHARMACIA & UPJOHN COMPANY (US) 1996-07-10 EP disclosed
WO-1995007901-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES THE UPJOHN COMPANY (US) 1995-03-23 WO disclosed