Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254236 | 0.95 | CTSL (0.55) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL28190849 | 0.87 | CTSL (0.54) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL3188496 | 0.87 | CTSK (0.53) | CTSKCTSSCTSLALDH1A1CTSB | |
| SCHEMBL16862505 | 0.87 | CTSK (0.53) | CTSKCTSSCTSLALDH1A1CTSB | |
| SCHEMBL7761583 | 0.86 | CTSS (0.55) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL15569565 | 0.86 | CTSS (0.55) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL5550159 | 0.86 | CTSS (0.55) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL6254290 | 0.85 | CASP1 (0.57) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL27617576 | 0.85 | CTSS (0.54) | CTSKCTSSCTSLALDH1A1CYP3A4 | |
| SCHEMBL4452037 | 0.85 | CASP1 (0.57) | CTSKCTSSCTSLALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204652-A1 | NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009110-A1 | NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-02-08 | — | — | WO | disclosed |