Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 13/20 | 0.57 |
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452037 | 1.00 | CASP1 (0.57) | CASP1CTSLCTSSALDH1A1CYP3A4 | |
| SCHEMBL15569565 | 0.89 | CTSS (0.55) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL7761583 | 0.89 | CTSS (0.55) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL5550159 | 0.89 | CTSS (0.55) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL2026643 | 0.88 | SIRT2 (0.52) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL751179 | 0.88 | CTSL (0.55) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL15569270 | 0.88 | CTSS (0.57) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL27617576 | 0.88 | CTSS (0.54) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL4280669 | 0.87 | CASP1 (0.67) | CASP1 | |
| SCHEMBL4280674 | 0.87 | CASP1 (0.67) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1231212-C | Polycyclic compounds that inhibit VLA-4 mediated leukocyte adhesion | ELAN PHARM INC (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1578735-A1 | CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS | Pfizer Limited (GB) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056787-A1 | CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS | PFIZER LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |