Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368010 | 0.89 | FLT3 (0.46) | FLT3MAP4K1JAK2JAK1CSNK2A1 | |
| SCHEMBL7367977 | 0.87 | JAK2 (0.46) | FLT3MAP4K1JAK2JAK1ALDH1A1 | |
| SCHEMBL7371218 | 0.85 | MEN1 (0.53) | FLT3MAP4K1CSNK2A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7366495 | 0.84 | FLT3 (0.45) | FLT3MAP4K1JAK2JAK1ALDH1A1 | |
| SCHEMBL7369363 | 0.83 | TP53 (0.50) | KDRSMN1; SMN2LMNANAMPT | |
| SCHEMBL7370817 | 0.80 | HTT (0.51) | FLT3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7365502 | 0.79 | JAK2 (0.41) | FLT3MAP4K1JAK2JAK1CSNK2A1 | |
| SCHEMBL7367473 | 0.79 | SMN1; SMN2 (0.46) | FLT3ALDH1A1SMN1; SMN2LMNACDK2 | |
| SCHEMBL7373717 | 0.79 | NR1H4 (0.57) | FLT3KDRSMN1; SMN2 | |
| SCHEMBL7368426 | 0.77 | NPC1 (0.54) | FLT3RXFP1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019045-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1019045-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999000128-A9 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 1999-08-05 | — | — | WO | disclosed |
| WO-1999000128-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | WO | disclosed |