Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FADS1 | O60427 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366495 | 0.89 | FLT3 (0.45) | JAK2JAK1FLT3MAP4K1ALDH1A1 | |
| SCHEMBL7366169 | 0.87 | FLT3 (0.43) | JAK2JAK1FLT3MAP4K1ALDH1A1 | |
| SCHEMBL7368010 | 0.85 | FLT3 (0.46) | JAK2JAK1FLT3MAP4K1ALDH1A1 | |
| SCHEMBL7370817 | 0.84 | HTT (0.51) | FLT3ALDH1A1LMNARAB9AP2RX1 | |
| SCHEMBL7365502 | 0.84 | JAK2 (0.41) | JAK2JAK1FLT3MAP4K1ALDH1A1 | |
| SCHEMBL7373717 | 0.83 | NR1H4 (0.57) | FLT3 | |
| SCHEMBL7368426 | 0.81 | NPC1 (0.54) | FLT3CDK2NPC1RAB9A | |
| SCHEMBL7371977 | 0.81 | NR1H4 (0.46) | FLT3NAMPT | |
| SCHEMBL7371218 | 0.80 | MEN1 (0.53) | FLT3MAP4K1ALDH1A1LMNARAB9A | |
| SCHEMBL7367473 | 0.80 | SMN1; SMN2 (0.46) | FLT3ALDH1A1LMNACDK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019045-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1019045-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999000128-A9 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 1999-08-05 | — | — | WO | disclosed |
| WO-1999000128-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | WO | disclosed |