Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.34 |
| ▸ | PLG | P00747 | 5/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | NPR3 | P17342 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | HPN | P05981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365021 | 0.89 | MMP2 (0.36) | PLAUPLGPLAT | |
| SCHEMBL7363440 | 0.88 | POLB (0.40) | PLGF2NPR3ALDH1A1F10 | |
| SCHEMBL7366260 | 0.87 | PLAU (0.39) | PLAUPLGF2PLATALDH1A1 | |
| SCHEMBL7050306 | 0.85 | PLAU (0.37) | PLAUPLGF2PLATALDH1A1 | |
| SCHEMBL7367638 | 0.83 | S1PR1 (0.40) | PLAUF2ALDH1A1 | |
| SCHEMBL6433416 | 0.82 | PLAU (0.32) | PLAUPLGF2NPR3F10 | |
| SCHEMBL7374993 | 0.81 | PLAU (0.42) | PLAUPLGF2PLATALDH1A1 | |
| SCHEMBL7375649 | 0.80 | NR1D1 (0.35) | PLAUPLGALDH1A1 | |
| Hydrochloric Acid SCHEMBL7369278 | 0.80 | PLAU (0.36) | PLAUPLGPLAT | |
| SCHEMBL7050066 | 0.80 | PLAU (0.39) | PLAUALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |