Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050306 | 0.91 | PLAU (0.37) | S1PR1PLAUF2TMPRSS6ALDH1A1 | |
| SCHEMBL7374054 | 0.86 | PLAU (0.38) | PLAUF2TMPRSS6ALDH1A1PDK1 | |
| SCHEMBL7375649 | 0.83 | NR1D1 (0.35) | PLAUALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL7370338 | 0.83 | PLAU (0.34) | PLAUF2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7363441 | 0.83 | PLAU (0.53) | PLAUPDK1PDK2PDK3PDK4 | |
| SCHEMBL7050066 | 0.82 | PLAU (0.39) | PLAUALDH1A1 | |
| SCHEMBL7363404 | 0.82 | DGAT2 (0.41) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7366260 | 0.81 | PLAU (0.39) | PLAUF2ALDH1A1PDK1PDK2 | |
| SCHEMBL7365021 | 0.81 | MMP2 (0.36) | PLAU | |
| SCHEMBL6433064 | 0.81 | S1PR1 (0.38) | S1PR1PLAUF2TMPRSS6TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |