Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370627 | 0.84 | MAOB (0.51) | MAOBIDO1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7370353 | 0.80 | MAOB (0.53) | MAOBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL7362866 | 0.79 | MEN1 (0.44) | IDO1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7365581 | 0.77 | CDK8 (0.48) | NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7369411 | 0.75 | RAB9A (0.42) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL7364174 | 0.74 | KDR (0.46) | NPC1RAB9ASMN1; SMN2KMT2ADCUN1D1 | |
| SCHEMBL28647816 | 0.72 | MAOB (0.45) | MAOBIDO1NPC1RAB9ACSNK1D | |
| SCHEMBL7368926 | 0.72 | CDK4 (0.47) | MAOBIDO1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7360220 | 0.72 | MAP2K4 (0.40) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL7367836 | 0.71 | IKBKB (0.42) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |