Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 6/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366344 | 0.84 | MAOB (0.50) | MAOBIDO1ALDH1A1CYP1A2HPGD | |
| SCHEMBL7370353 | 0.81 | MAOB (0.53) | MAOBADORA2AADORA1NOTUMALDH1A1 | |
| SCHEMBL7362866 | 0.80 | MEN1 (0.44) | IDO1KDM4EALDH1A1KMT2A | |
| SCHEMBL7412116 | 0.79 | NUDT1 (0.47) | MAOBIDO1NUDT1ADORA2AADORA1 | |
| SCHEMBL7365581 | 0.78 | CDK8 (0.48) | ALDH1A1HPGDKDM5B | |
| SCHEMBL7369411 | 0.77 | RAB9A (0.42) | KDM4EALDH1A1CYP1A2HPGDKMT2A | |
| SCHEMBL7364174 | 0.75 | KDR (0.46) | ADORA2AADORA1KDM4EALDH1A1KMT2A | |
| SCHEMBL7360220 | 0.73 | MAP2K4 (0.40) | KDM4EALDH1A1CYP1A2HPGDKMT2A | |
| SCHEMBL7368926 | 0.73 | CDK4 (0.47) | MAOBIDO1ADORA1KDM4EALDH1A1 | |
| SCHEMBL7367836 | 0.72 | IKBKB (0.42) | IKBKBCHUKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |