Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29642997 | 0.79 | KMT2A (0.49) | KMT2AALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL742725 | 0.79 | KMT2A (0.49) | KMT2AALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL27456780 | 0.77 | PTGS2 (0.38) | KMT2AALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL7339899 | 0.77 | KMT2A (0.40) | KMT2AALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL7129180 | 0.77 | KDM4E (0.44) | KMT2AALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4314520 | 0.75 | RAPGEF4 (0.41) | ALDH1A1KDM4EF2MAPTGAA | |
| SCHEMBL2697009 | 0.75 | MAOA (0.45) | KMT2AALDH1A1HTTKDM4EF2 | |
| SCHEMBL15068288 | 0.73 | RAPGEF4 (0.42) | KMT2AALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29627448 | 0.73 | TRPV4 (0.42) | KMT2AALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2426442 | 0.73 | TRPV4 (0.42) | KMT2AALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997046207-A2 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0804464-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996018644-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1996-06-20 | — | — | WO | disclosed |