Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783064 | 0.83 | CYP2C9 (0.47) | LMNAMAPTL3MBTL1 | |
| SCHEMBL903959 | 0.81 | EPHX1 (0.46) | KMT2ALMNAMAPTGAAL3MBTL1 | |
| SCHEMBL5094461 | 0.78 | ALDH1A1 (0.52) | KMT2ALMNAMAPTTDP1PKM | |
| SCHEMBL28043834 | 0.77 | PKM (0.43) | LMNAPOLBMAPK1MAPTPKM | |
| SCHEMBL20563537 | 0.77 | IDO1 (0.41) | KMT2APOLBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL20540763 | 0.75 | LMNA (0.65) | KMT2ALMNAMAPK1MAPTTDP1 | |
| SCHEMBL8329718 | 0.73 | PIN1 (0.50) | KMT2APOLBMAPTTDP1PKM | |
| SCHEMBL20664948 | 0.72 | KMT2A (0.44) | KMT2ALMNAMAPTTDP1PKM | |
| SCHEMBL6965136 | 0.72 | LMNA (0.46) | LMNAPOLBMAPK1MAPTPKM | |
| SCHEMBL27684874 | 0.71 | LMNA (0.49) | KMT2ALMNAMAPTPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730590-B1 | ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | DU PONT PHARM CO (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| WO-2000024722-A1 | 2,3-DIHYDRO-4-OXO-4H-1,3-OXAZINE AND 2-OXO-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | AVENTIS CROPSCIENCE S.A. (FR) | 2000-05-04 | — | — | WO | disclosed |
| EP-0970950-A2 | Novel isoxazoline and isoxazole fibrinogen receptor antagonists | DuPont Pharmaceuticals Company (US) | 2000-01-12 | — | — | EP | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0730590-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014683-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |