Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369173 | 0.83 | NISCH (0.35) | SIGMAR1HTR2C | |
| SCHEMBL7360100 | 0.83 | SIGMAR1 (0.49) | SIGMAR1HTR2C | |
| SCHEMBL120894 | 0.80 | SIGMAR1 (0.47) | SIGMAR1HTR2CHTR2AHTR6F2 | |
| SCHEMBL9404131 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR2CDRD2DRD4DRD3 | |
| SCHEMBL16371769 | 0.74 | SIGMAR1 (0.42) | SIGMAR1HTR2CHTR2AHTR6F2 | |
| SCHEMBL5265951 | 0.73 | POLB (0.44) | SIGMAR1HTR2C | |
| SCHEMBL25334138 | 0.72 | F2 (0.48) | SIGMAR1HTR2CF2ALDH1A1LMNA | |
| SCHEMBL7808380 | 0.71 | DRD2 (0.48) | SIGMAR1HTR2CDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL6586236 | 0.71 | HTR2C (0.41) | SIGMAR1HTR2CF2 | |
| SCHEMBL9868832 | 0.71 | SIGMAR1 (0.39) | SIGMAR1HTR2CDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |