Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 2/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371668 | 0.86 | ADORA2A (0.37) | CYP11B1CYP11B2ADORA1METPIM1 | |
| SCHEMBL7364069 | 0.86 | PDE1A (0.39) | CYP11B1CYP11B2ADORA1 | |
| SCHEMBL7362751 | 0.83 | MAPK14 (0.42) | ADORA1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL7362732 | 0.83 | BMPR1B (0.37) | CYP11B1CYP11B2ADORA1BMPR1BBMPR1A | |
| SCHEMBL7366115 | 0.82 | USP2 (0.35) | MAT2ACYP11B1ADORA1BMPR1BBMPR1A | |
| SCHEMBL5673343 | 0.82 | ADORA2A (0.40) | MAT2AADORA1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL6824626 | 0.81 | NPC1 (0.36) | MAT2A | |
| SCHEMBL7363632 | 0.80 | BMPR1B (0.37) | ADORA1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL7365171 | 0.79 | BMPR1B (0.36) | ADORA1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL7363841 | 0.78 | PDE3A (0.45) | CYP11B1CYP11B2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |