Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362751 | 0.88 | MAPK14 (0.42) | PTGS2ADORA1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL7362732 | 0.87 | BMPR1B (0.37) | USP2ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL7363632 | 0.83 | BMPR1B (0.37) | PTGS2ADORA1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL7367567 | 0.82 | MAT2A (0.33) | ADORA1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL7365171 | 0.82 | BMPR1B (0.36) | USP2CYP1A2TSHRADORA1BMPR1B | |
| SCHEMBL7367166 | 0.80 | BRD4 (0.44) | USP2ALDH1A1TSHRADORA1BMPR1B | |
| SCHEMBL7401220 | 0.79 | PDE3A (0.41) | USP2ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL7364069 | 0.77 | PDE1A (0.39) | ALDH1A1CYP1A2CYP3A4TSHRCLK4 | |
| SCHEMBL7039587 | 0.74 | ADORA1 (0.57) | ADORA1MAPK14 | |
| SCHEMBL7036702 | 0.74 | BMPR1B (0.34) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |