Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 8/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369589 | 0.87 | PDE3A (0.39) | PDE3APDE5APDE3BCYP1A2AKR1B1 | |
| SCHEMBL7399130 | 0.84 | PDE3A (0.45) | PDE3APDE5APDE3BCYP1A2KDM4E | |
| SCHEMBL7369957 | 0.84 | PDE3A (0.48) | PDE3APDE5APIM1PDE3BCYP1A2 | |
| SCHEMBL7366330 | 0.82 | PDE3A (0.40) | PDE3APDE5APDE3BCYP1A2ALDH1A1 | |
| SCHEMBL7401220 | 0.81 | PDE3A (0.41) | PDE3APDE5APIM1PDE3BCYP1A2 | |
| SCHEMBL7371668 | 0.80 | ADORA2A (0.37) | PIM1ALDH1A1CYP11B1CYP11B2F10 | |
| SCHEMBL5671032 | 0.80 | PIM1 (0.40) | PIM1KDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL6821911 | 0.79 | PDE3A (0.44) | PDE3APDE5APDE3BCYP1A2KDM4E | |
| SCHEMBL7367567 | 0.78 | MAT2A (0.33) | PIM1CYP11B1CYP11B2 | |
| SCHEMBL7395677 | 0.78 | PDE3A (0.42) | PDE3APDE5APDE3BCYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |