Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5942690 | 0.83 | PDE4A (0.40) | PDE4AKCNH2 | |
| SCHEMBL7395938 | 0.78 | PDE4A (0.51) | PDE4AKCNH2 | |
| SCHEMBL7908346 | 0.75 | PDE4A (0.67) | PDE4AKCNH2 | |
| SCHEMBL7908376 | 0.73 | PDE4A (0.44) | PDE4A | |
| SCHEMBL7989179 | 0.73 | PDE4A (0.37) | PDE4AKCNH2 | |
| SCHEMBL7908336 | 0.73 | PDE4A (0.38) | PDE4AKCNH2 | |
| SCHEMBL5942728 | 0.72 | PDE4A (0.52) | PDE4AKCNH2 | |
| SCHEMBL10633324 | 0.72 | NR3C1 (0.41) | — | |
| SCHEMBL7906572 | 0.71 | PDE4A (0.51) | PDE4AKCNH2 | |
| SCHEMBL7991261 | 0.71 | HSPB1 (0.48) | PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189888-A1 | HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS $i(PDE 4) INHIBITORS | Merck Frosst Canada & Co. (CA) | 2002-03-27 | — | — | EP | disclosed |
| US-6316472-B1 | Heterosubstituted pyridine derivatives as PDE 4 inhibitors | MERCK FROSST CANADA & CO. (CA) | 2001-11-13 | — | — | US | disclosed |
| US-6200993-B1 | ASTHMA; ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-03-13 | — | — | US | disclosed |
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |
| WO-2000069824-A1 | HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2000-11-23 | — | — | WO | disclosed |