Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5942886 | 0.90 | MAPK1 (0.37) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL7996011 | 0.80 | LMNA (0.41) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL7904298 | 0.80 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7991279 | 0.80 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL7992704 | 0.80 | F7 (0.36) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL7994826 | 0.78 | PDE4B (0.33) | PDE4APDE4BPDE4CPDE4DFBP1 | |
| SCHEMBL7911732 | 0.76 | PDE4A (0.39) | PDE4AKCNH2 | |
| SCHEMBL7367599 | 0.73 | PDE4A (0.43) | PDE4AKCNH2 | |
| SCHEMBL7908346 | 0.72 | PDE4A (0.67) | PDE4AKCNH2 | |
| SCHEMBL5942690 | 0.68 | PDE4A (0.40) | PDE4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316472-B1 | Heterosubstituted pyridine derivatives as PDE 4 inhibitors | MERCK FROSST CANADA & CO. (CA) | 2001-11-13 | — | — | US | disclosed |
| US-6200993-B1 | ASTHMA; ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-03-13 | — | — | US | disclosed |
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |