Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365777 | 0.89 | ADORA1 (0.39) | DPP4KCNH2DPP8DPP9KDM4C | |
| SCHEMBL7365779 | 0.89 | ADORA1 (0.39) | DPP4KCNH2DPP8DPP9KDM4C | |
| SCHEMBL7366165 | 0.84 | ADORA2A (0.38) | KDM4CTGFBR1EGFR | |
| SCHEMBL7367704 | 0.84 | ADORA1 (0.40) | DPP4KCNH2DPP8DPP9CYP1A2 | |
| SCHEMBL7367701 | 0.77 | ADORA1 (0.42) | DPP4KCNH2DPP8DPP9CNR2 | |
| SCHEMBL7371146 | 0.76 | ADORA1 (0.41) | DPP4KCNH2DPP8DPP9CNR2 | |
| SCHEMBL7367570 | 0.75 | NSD3 (0.48) | DPP4KCNH2DPP8DPP9CYP1A2 | |
| SCHEMBL6824299 | 0.74 | PDE1A (0.38) | DPP4DPP8DPP9PDE1APDE1B | |
| SCHEMBL6818764 | 0.74 | PDE1A (0.38) | DPP4DPP8DPP9PDE1APDE1B | |
| SCHEMBL6818413 | 0.74 | PDE1A (0.38) | DPP4DPP8DPP9PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |