Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365777 | 0.91 | ADORA1 (0.39) | ADORA2AADORA2BADORA1KDM4CMEN1 | |
| SCHEMBL7365779 | 0.91 | ADORA1 (0.39) | ADORA2AADORA2BADORA1KDM4CMEN1 | |
| SCHEMBL7367704 | 0.85 | ADORA1 (0.40) | ADORA1GSK3BCSNK1DCSNK1EMEN1 | |
| SCHEMBL7364072 | 0.84 | DPP4 (0.43) | KDM4CEGFRTGFBR1 | |
| SCHEMBL7367701 | 0.78 | ADORA1 (0.42) | ADORA1 | |
| SCHEMBL7371146 | 0.77 | ADORA1 (0.41) | ADORA1 | |
| SCHEMBL7367570 | 0.76 | NSD3 (0.48) | ADORA1CASP1CASP7HIF1A | |
| SCHEMBL7362751 | 0.75 | MAPK14 (0.42) | ADORA2AADORA2BADORA1MAPK14EGFR | |
| SCHEMBL6818764 | 0.73 | PDE1A (0.38) | ADORA1 | |
| SCHEMBL6824299 | 0.73 | PDE1A (0.38) | ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |