Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362436 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AMKNK1MKNK2 | |
| SCHEMBL7361314 | 0.91 | TBXAS1 (0.46) | SMN1; SMN2MEN1KMT2AMKNK1MKNK2 | |
| SCHEMBL7360999 | 0.90 | HPGD (0.53) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7367933 | 0.87 | ALDH1A1 (0.56) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7370600 | 0.85 | MEN1 (0.51) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7362202 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7367921 | 0.83 | PDE4A (0.53) | SMN1; SMN2MKNK1MKNK2ALDH1A1CAMKK2 | |
| SCHEMBL7370605 | 0.82 | KDM4E (0.48) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7363949 | 0.82 | TBXAS1 (0.46) | SMN1; SMN2MKNK1MKNK2TP53MAPT | |
| SCHEMBL7369488 | 0.81 | HPGD (0.50) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |