Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370566 | 0.90 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7372162 | 0.90 | RAB9A (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7370605 | 0.87 | KDM4E (0.48) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7360999 | 0.86 | HPGD (0.53) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7370206 | 0.85 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7367933 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7366591 | 0.83 | ALDH1A1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7364065 | 0.82 | PDE4A (0.57) | SMN1; SMN2ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL7365437 | 0.81 | PDE4A (0.43) | MEN1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL7370212 | 0.81 | PDE4A (0.59) | MEN1KMT2AALDH1A1L3MBTL1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |