Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332693 | 0.83 | ALDH1A1 (0.61) | RAB9APTGER4ALDH1A1POLBGAA | |
| SCHEMBL4445418 | 0.83 | PTGER4 (0.60) | PTGER4LMNASMN1; SMN2XDHSLC22A12 | |
| SCHEMBL7369234 | 0.83 | L3MBTL1 (0.52) | RAB9AALDH1A1POLBTDP1SMN1; SMN2 | |
| SCHEMBL7368260 | 0.82 | POLB (0.58) | RAB9AALDH1A1POLBGAATDP1 | |
| SCHEMBL5216488 | 0.81 | TDP1 (0.56) | RAB9AALDH1A1TDP1LMNASMN1; SMN2 | |
| SCHEMBL2779334 | 0.81 | RAB9A (0.76) | RAB9AALDH1A1POLBGAATDP1 | |
| SCHEMBL7368043 | 0.78 | POLB (0.48) | ALDH1A1POLBGAA | |
| SCHEMBL7372157 | 0.78 | RAB9A (0.49) | RAB9AALDH1A1POLBGAATDP1 | |
| SCHEMBL7320114 | 0.78 | RAB9A (0.55) | RAB9AALDH1A1POLBGAATDP1 | |
| SCHEMBL861902 | 0.78 | TDP1 (0.71) | RAB9AALDH1A1POLBGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |