Sugi Predict

Sugi Predict / Compounds / SCHEMBL736818

SCHEMBL736818

SCHEMBL736818

CC(C)OC(=O)N(C)c1ccc(N)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.59
▸ HTT P42858 1/20 0.59
▸ NPSR1 Q6W5P4 1/20 0.59
▸ MAPK1 P28482 3/20 0.42
▸ ALOX15 P16050 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ TDP1 Q9NUW8 2/20 0.42
▸ TP53 P04637 1/20 0.42
▸ SYK P43405 2/20 0.41
▸ CHRNB2 P17787 3/20 0.40
▸ CHRNB4 P30926 3/20 0.40
▸ CHRNA3 P32297 3/20 0.40
▸ CHRNA4 P43681 3/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ GAA P10253 1/20 0.38
▸ NR1H3 Q13133 1/20 0.38
▸ PPIB P23284 2/20 0.37
▸ MAPT P10636 2/20 0.36
▸ CASP1 P29466 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3507290 0.81 LMNA (0.58) LMNAHTTNPSR1ALDH1A1CHRNB2
SCHEMBL12282970 0.81 HTT (0.57) LMNAHTTNPSR1ALDH1A1TDP1
SCHEMBL737365 0.79 ALDH1A1 (0.46) LMNAHTTNPSR1MAPK1ALOX15
SCHEMBL2536746 0.79 NPSR1 (0.55) LMNAHTTNPSR1MAPK1ALDH1A1
SCHEMBL514411 0.78 CYP3A4 (0.45) LMNAHTTNPSR1MAPK1ALOX15
SCHEMBL14350001 0.77 LMNA (0.54) LMNAHTTNPSR1MAPK1ALDH1A1
SCHEMBL1817649 0.75 PAX8 (0.49) LMNAHTTNPSR1MAPK1ALOX15
SCHEMBL11444462 0.75 LMNA (0.59) LMNAMAPK1ALOX15ALDH1A1CYP3A4
SCHEMBL12550500 0.74 ALDH1A1 (0.54) LMNAMAPK1ALOX15ALDH1A1CYP3A4
SCHEMBL13734403 0.72 ALDH1A1 (0.52) LMNAMAPK1ALOX15ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11414410-B2 Inhibitors of protein kinases ALEXION PHARMACEUTICALS, INC. (US) 2022-08-16 — — US disclosed
US-20200239458-A1 INHIBITORS OF PROTEIN KINASES ALEXION PHARMACEUTICALS, INC. 2020-07-30 — — US disclosed
US-20180186783-A1 INHIBITORS OF PROTEIN KINASES ALEXION PHARMACEUTICALS, INC. 2018-07-05 — — US disclosed
US-9868729-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2018-01-16 — — US disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 — — US disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20150094298-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. 2015-04-02 — — US disclosed
US-20150080426-A1 BENZOQUINOLINE INHIBITORS OF VMAT 2 AUSPEX PHARMACEUTICALS, INC. 2015-03-19 — — US disclosed
US-8937070-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2015-01-20 — — US disclosed
US-20140031361-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. 2014-01-30 — — US disclosed
US-8501944-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2013-08-06 — — US disclosed
US-20120129867-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2012-05-24 — — US disclosed
US-8138339-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-03-20 — — US disclosed
EP-2321283-A1 2, 6-DIAMINO-PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS Portola Pharmaceuticals, Inc. (US) 2011-05-18 — — EP disclosed
EP-1663211-B1 AMINOTRIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES VERTEX PHARMA (US) 2010-01-20 — — EP disclosed
US-20090318407-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-24 — — US disclosed
WO-2009145856-A1 2, 6-DIAMINO-PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318407-A1 Inhibitors of protein kinases SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK LMNA 3243/4885HTT 3171/4885NPSR1 4201/4885
US-20120129867-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885
US-20150080426-A1 BENZOQUINOLINE INHIBITORS OF VMAT 2 SLC18A2, ACAT2, SLC6A2 LMNA 2477/4885HTT 520/4885NPSR1 1721/4885
US-20200239458-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885
US-20180186783-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885
US-11414410-B2 Inhibitors of protein kinases MAP3K1, MAP3K20, MAP3K2 LMNA 3562/4885HTT 4353/4885NPSR1 3385/4885
US-20140031361-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885
US-20150094298-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK1 LMNA 4015/4885HTT 1002/4885NPSR1 3053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.