SCHEMBL7368517

SCHEMBL7368517

NC(=O)C(C(=O)N(Cc1ccccc1)C1CCNCC1)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 1/20 0.47
ALOX5 P09917 2/20 0.46
MBTPS1 Q14703 3/20 0.45
KCNH2 Q12809 1/20 0.43
PARP10 Q53GL7 1/20 0.43
HTR2A P28223 2/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
TACR1 P25103 1/20 0.41
DCUN1D1 Q96GG9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7370864 0.94 MBTPS1 (0.52) CACNA1BALOX5MBTPS1KCNH2SLC6A2
SCHEMBL7366435 0.78 MBTPS1 (0.47) ALOX5MBTPS1KCNH2SLC6A2SLC6A4
SCHEMBL7373750 0.77 ALOX5 (0.45) ALOX5KCNH2PARP10
SCHEMBL6202628 0.75 HTR2A (0.51) KCNH2HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL6622412 0.75 DCUN1D1 (0.54) KCNH2SLC6A2SLC6A4SLC6A3TACR1
SCHEMBL3811903 0.74 DCUN1D1 (0.58) KCNH2SLC6A2SLC6A4SLC6A3TACR1
SCHEMBL27787053 0.74 SLC6A4 (0.61) KCNH2SLC6A2SLC6A4SLC6A3DCUN1D1
SCHEMBL3716947 0.73 HTR2A (0.73) KCNH2HTR2ASLC6A2SLC6A3DCUN1D1
Hydrochloric Acid SCHEMBL21410210 0.73 DCUN1D1 (0.57) KCNH2SLC6A2SLC6A4SLC6A3TACR1
SCHEMBL7368515 0.72 CACNA1B (0.44) CACNA1BMBTPS1KCNH2HTR2ASLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998054123-A1 SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS WARNER-LAMBERT COMPANY (US) 1998-12-03 WO claimed
WO-1998054123-A1 SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS WARNER-LAMBERT COMPANY (US) 1998-12-03 WO disclosed