Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 10/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761733 | 0.81 | MAOB (0.61) | SIRT1MAOBADORA2BRAB9ANPC1 | |
| SCHEMBL27612856 | 0.79 | NAPRT (0.73) | NAPRTTP53MAPTALOX15KMT2A | |
| SCHEMBL31314554 | 0.74 | MAOB (0.50) | SIRT1MAOBADORA2BRAB9ANPC1 | |
| SCHEMBL28245010 | 0.74 | MAOB (0.52) | SIRT1MAOBADORA2BRAB9ANPC1 | |
| SCHEMBL11856874 | 0.73 | KMT2A (0.50) | SIRT1MAOBADORA2BRAB9ANPC1 | |
| SCHEMBL5653339 | 0.72 | NAPRT (0.67) | NAPRTRAB9ANPC1MAPTALOX15 | |
| SCHEMBL6345667 | 0.72 | KMT2A (0.61) | SIRT1MAOBADORA2BRAB9ANPC1 | |
| SCHEMBL7370739 | 0.71 | GPR84 (0.66) | NAPRTRAB9ANPC1TP53MAPT | |
| SCHEMBL70456 | 0.69 | MAOB (0.76) | MAOBADORA2BRAB9ANPC1TP53 | |
| SCHEMBL11734978 | 0.69 | MAOB (0.48) | SIRT1MAOBADORA2BRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |