Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162463 | 0.84 | TRPV4 (0.44) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL65955 | 0.79 | MEN1 (0.56) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL29500393 | 0.79 | MEN1 (0.56) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL6240708 | 0.74 | CCR4 (0.44) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL29434897 | 0.74 | CCR4 (0.44) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL17850502 | 0.74 | TRPV4 (0.44) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL30681743 | 0.74 | SLC22A12 (0.39) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL6254835 | 0.74 | HSD11B1 (0.40) | MEN1KMT2AHSD11B1SLC22A12TRPV4 | |
| SCHEMBL3199583 | 0.74 | HSD11B1 (0.49) | HSD11B1P2RX7ALDH1A1 | |
| SCHEMBL27152694 | 0.74 | SLC22A12 (0.39) | MEN1KMT2AHSD11B1SLC22A12TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034215-A | 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors | CORVAS INTERNATIONAL, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1997046207-A2 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0804464-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0802923-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0765339-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES CONTAINING AN ARGININE MIMIC AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1996018644-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1996-06-20 | — | — | WO | disclosed |
| WO-1995035311-A9 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | — | 1996-02-01 | — | — | WO | disclosed |
| WO-1995035313-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES CONTAINING AN ARGININE MIMIC AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |
| WO-1995035311-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |